Potassium Chloride (KCl) IV Administration. Potassium phosphate is used to treat or prevent hypophosphatemia (low blood levels of phosphorus). Monopotassium phosphate, MKP, (also potassium dihydrogenphosphate, KDP, or monobasic potassium phosphate), KH2PO4, is a soluble salt of potassium and the dihydrogen phosphate ion. Hyperkalemia (high potassium in the blood) or, Hyperphosphatemia (high phosphorus in the blood) or, Hypocalcemia (low calcium in the blood) or. 1. Make sure you tell your doctor if you have any other medical problems, especially: A nurse or other trained health professional will give you potassium phosphate in a medical facility. Therefore, if ordering 30 mmol of potassium phosphate, the patient will receive ~45 mEq of potassium. Monobasic Potassium Phosphate – 224 mg : 285 mg (3 mmol) 170 mg . Drugs, 2010 Potassium phosphate is sometimes added to intravenous (IV) fluids given to people who cannot eat or drink anything. You may report side effects to the FDA at 1-800-FDA-1088. Compare formulary status to other drugs in the same class. Data are very limited in children; doses as high as 1 mmol/kg/dose IV over 12 hours have been reported in pediatric patients with DKA and severe hypophosphatemia. Although not all of these side effects may occur, if they do occur they may need medical attention. IV: Injection must be diluted in appropriate IV solution and volume prior to administration. Do not take other medicines unless they have been discussed with your doctor. Available for Android and iOS devices. Cease IV potassium administration and notify M.O if serum potassium is greater than or Potassium . Drug information provided by: IBM Micromedex Along with its needed effects, a medicine may cause some unwanted effects. Hypomagnesemia (low magnesium in the blood)—Use with caution. DESCRIPTION. How to use Potassium Phosphate 20 Mmol/250 Ml In Dextrose 5% Intravenous Solution Consult your pharmacist or physician. Check tubing below Y-site carefully for discoloration, cloudiness or precipitation These side effects may go away during treatment as your body adjusts to the medicine. Potassium phosphate contains aluminum which can cause harm especially to premature babies. • Always dilute KCl, never give a bolus or IV push. Potassium Phosphate Each mL of potassium phosphate contains 4.4 milliequivalents (mEq) of potassium and 3 millimoles (mmol) of phosphate. commonly, these are "non-preferred" brand drugs. 20 meq KCl PO/PT/IV X 3 doses (IV route preferred) immediately and with next AM labs. MiraLAX, senna, Colace, docusate, ergocalciferol, magnesium citrate, multivitamin, biotin, ascorbic acid, calcium / vitamin d. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Expert sources advise for peripheral intravenous administration the concentration of potassium should not usually exceed 40 mmol/litre; the infusion solution should be thoroughly mixed.Local policies on avoiding inadvertent use of potassium concentrate should be followed. commonly, these are generic drugs. This website also contains material copyrighted by 3rd parties. Although not all of these side effects may occur, if they do occur they may need medical attention. Precautions. Potassium phosphate is to be given only by or under the direct supervision of a … By clicking send, you acknowledge that you have permission to email the recipient with this information. Blood and urine tests may be needed to check for unwanted effects. Drugs, encoded search term (potassium phosphates%2C IV ((potassium phosphates%2C IV))) and potassium phosphates, IV ((potassium phosphates, IV)), New Drug Approved for Neuroblastoma Based on MSKCC Research, SCORED and FIDELIO-DKD: Time for Cardiologists to Help, Not Hurt, the Kidney, A 2-Month-Old Boy With Yellow Eyes: Osmosis USMLE Study Question of the Week, Medscape Nephrologist Compensation Report 2018, New Guidelines Address Diabetes Management in Kidney Disease, Novel Drug Slows Progression of Diabetic Kidney Disease, 'Kidney' vs 'Renal': Experts Say Words Matter, Dapagliflozin Halves Hyperkalemia in Some HF Patients, Impaired Kidney Function Linked to Worse COVID-19 Outcomes. It can be used in fertilizer mixtures to reduce escape of ammonia by keeping pH low. If the serum potassium is ≥ 4.0 mg/dL, administer as sodium phosphate. Potassium Phosphate injection, Pfizer, 3 mmol/mL, 15 mL vial, 25 count, NDC 00409-7295-01 Glycophos injection, Fresenius Kabi, 1 mmol/mL, 20 mL vial, 10 count, … Check with your doctor right away if you start having dizziness, fainting, lightheadedness, seizures, or fast, slow, pounding, or uneven heartbeat. This drug is available at a middle level co-pay. sodium-phosphates-iv-999713 It is also used as an additive in the preparation of fluid formula injections. The presence of other medical problems may affect the use of potassium phosphate. Potassium phosphate is used to treat or prevent hypophosphatemia (low blood levels of phosphorus). Potassium phosphate is sometimes added to intravenous (IV) … Decide which phosphate salt should be administered. Potassium phosphate is to be given only by or under the direct supervision of a doctor. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. The following guidelines are evidence-based recommendations. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. • Phosphate replacement must be ordered in mmol of phosphorus. Some phosphate injection preparations also contain potassium. The above information is provided for general Select one or more newsletters to continue. Serum K+ Replace With Recheck Level 3.3-3.9 mEq/L. Either potassium phosphate or sodium phosphate injection may be used for IV phosphate … Access your plan list on any device – mobile or desktop. 30 mmol Potassium Phosphate IV over 4 HR (Administered as: 15 mmol Potassium Phosphate IV Q2H x 2 doses) Recheck serum phosphorus level 2 hours after infusion complete • If both potassium and phosphorus replacement required, subtract the mEq of potassium given as potassium phosphate from total amount of potassium required. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of potassium phosphate injection in the elderly. Individual plans may vary POTASSIUM sodium bicarbonate phosphate: ranitidine. Calculate concomitant amount of sodium that will be administered: Each 1 mmol of phosphate contains ~1.3 mEq of sodium; if amount of sodium to be delivered is a concern (ie, sodium serum level >145 mEq/L), consider use of potassium phosphates IV to replete phosphorous level The administration of potassium phosphate 30 mmol to severely hypophosphatemic patients was safe but achieved normalization of serum phosphate in a minority of patients. Potassium Phosphates Injection, USP is a sterile, nonpyrogenic, concentrated solution containing a mixture of mono and dibasic potassium phosphate in Water for Injection q.s. When you are receiving potassium phosphate, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. commonly, these are "preferred" (on formulary) brand drugs. Per P&T approval, automatically convert Intravenous sodium or potassium phosphate orders to oral phosphate if the adult patient meets all of the following criteria: a. Serum phosphate is greater than (>)1 mg/dL b. informational and educational purposes only. Drugs, 2010 In addition to inspection of solution; infusion set and catheter should also periodically be checked for precipitates, Therapy may increase risk of hyperkalemia, including life-threatening cardiac events, especially when administered in excessive doses, undiluted or by rapid intravenous infusion, Patients with severe renal impairment and end stage renal disease are at increased risk of developing life-threatening hyperkalemia when administered intravenous potassium, Other patients at increased risk of hyperkalemia include those with severe adrenal insufficiency or treated concurrently with other drugs that cause or increase risk of hyperkalemia; patients with cardiac disease may be more susceptible to effects of hyperkalemia, Consider amount of potassium from all sources when determining dose of drug and do not exceed maximum age-appropriate recommended daily amount of potassium; in patients with moderate renal impairment (eGFR ≥30 mL/min/1.73 m, When administering in intravenous fluids to correct hypophosphatemia, check serum potassium concentration prior to administration; if potassium concentration is 4 mEq/dL or more, do not administer drug and use alternative source of phosphate, Maximum initial or single dose in intravenous fluids to correct hypophosphatemia is phosphorus 45 mmol (potassium 71 mEq); recommended infusion rate of potassium is 10 mEq/hour; continuous electrocardiographic (ECG) monitoring is recommended for higher infusion rates of potassium, Hyperphosphatemia can occur with intravenous administration of potassium phosphates, especially in patients with renal impairment; hyperphosphatemia can cause formation of insoluble calcium phosphorus products with consequent hypocalcemia, neurological irritability with tetany, nephrocalcinosis with acute kidney injury and more rarely, cardiac irritability with arrhythmias, Obtain serum calcium concentrations prior to administration and normalize calcium before administering therapy; monitor serum phosphorus and calcium concentrations during treatment, This product contains aluminum that may be toxic; aluminum may reach toxic levels with prolonged parenteral administration if kidney function is impaired; premature neonates are at particular risk because of immature kidneys, Preterm infants are at risk for aluminum toxicity because their kidneys are immature, and they require large amounts of calcium and phosphate solutions, which also contain aluminum, Patients with renal impairment, including preterm infants, who receive greater than 4 - 5 mcg/kg/day of parenteral aluminum can accumulate aluminum to levels associated with central nervous system and bone toxicity; tissue loading may occur at even lower rates of administration, Exposure to aluminum from therapy is not more than 4.9 mcg/kg/day when adults weighing at least 45 kg are administered recommended maximum dosage of phosphorus (45 mmol/day) for parenteral nutrition or pediatric patients 12 years of age and older weighing at least 40 kg are administered recommended maximum dosage of phosphorus (40 mmol/day) for parenteral nutrition, When prescribing therapy for use in parenteral nutrition solutions containing other small volume parenteral products, total daily patient exposure to aluminum from admixture should be considered and maintained at no more than 5 mcg/kg/day, When used for parenteral nutrition not recommended in adults weighing <45 kg or pediatric patients <12 years of age or weighing <40 kg due to risks of aluminum toxicity, Pediatric patients 12 years of age and older weighing at least 40 kg are administered recommended maximum dosage of phosphorus (40 mmol/day) for parenteral nutrition, Tissue accumulation may occur at even lower doses, Drug must be diluted and administered in intravenous fluids or used as an admixture in parenteral nutrition; not for direct intravenous infusion; infusion of hypertonic solutions into a peripheral vein may result in vein irritation, vein damage, and/or thrombosis, The primary complication of peripheral administration is venous thrombophlebitis, which manifests as pain, erythema, tenderness or a palpable cord; remove catheter as soon as possible and initiate appropriate medical treatment if thrombophlebitis develops, When administered peripherally in intravenous fluids to correct hypophosphatemia, a generally recommended maximum concentration is phosphorus 6.4 mmol/100 mL (potassium 10 mEq/100 mL), Parenteral nutrition solutions with an osmolarity of 900 mOsm/L or greater must be infused through a central catheter, Acyclovir, amiodarone, amphotericin B lipid complex (Abelcet), amphotericin B liposome (AmBisome), anidulafungin, caspofungin, ciprofloxacin, daunorubicin liposome, doripenem, doxacurium, doxorubicin, epirubicin, gemtuzumab ozogamicin, idarubicin, ifosfamide, ketamine, lansoprazole, leucovorin calcium, lorazepam, mitoxantrone, mycophenolate, pantoprazole, quinupristin/dalfopristin, rocuronium, D10% in 0.9% NaCl; D2.5% in Half-strength LR; D5% in LR; Dextrose 5% in Ringer's; Lactated Ringer's; Ringer's injection, Alemtuzumab, aminocaproic acid, argatroban, atenolol, bivalirudin, bleomycin, carboplatin, carmustine, cisplatin, cyclophosphamide, cytarabine, dactinomycin, daptomycin, dexmedetomidine, dexrazoxane, diltiazem, Magnesium sulfate, metoclopramide, verapamil, Dextran 70 6% in D5W; dextran 70 6% in 0.5% NaCl; D10W; D2.5W; D2.5/0.45% NaCl; D5/0.2% NaCl; D5/0.45% NaCl; D5/NS; 0.9% NaCl (NS); 0.45% NaCl; sodium lactate 1/6 M. View the formulary and any restrictions for each plan. Potassium Phosphates Injection, USP 3 mM P/mL (millimoles/mL) is a sterile, nonpyrogenic, concentrated solution containing a mixture of mono- and dibasic potassium phosphate in … Please confirm that you would like to log out of Medscape. Most Using potassium phosphate with any of the following medicines is usually not recommended, but may be required in some cases. potassium-phosphate-iv-999714 vancomycin: vitamin K. acyclovir ... IV fluid, concentration, order of mixing and brand of drug. The recipient will receive more details and instructions to access this offer. Last updated on Dec 17, 2019. Medically reviewed by Drugs.com. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. If you notice any other effects, check with your healthcare professional. A: Generally acceptable. 40 meq KCl PO/PT/IV (enteral route preferred) with next AM labs. Potassium phosphate is given to patients who cannot receive a phosphate supplement by mouth. You may report side effects to FDA at 1 … Pulmonary vascular emboli and pulmonary distress related to precipitates in pulmonary vasculature described in patients receiving admixed products containing calcium and phosphates or parenteral nutrition; Cause of precipitate formation has not been determined in all cases; however, in some fatal cases, pulmonary emboli occurred as a result of calcium phosphate precipitates; precipitation has occurred following passage through an in-line filter; If signs of pulmonary distress occur, stop parenteral nutrition infusion, and initiate medical evaluation. 2010 Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of potassium phosphate injection in children. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. This drug is available at the lowest co-pay. The dose and administration IV infusion rate for potassium phosphates are dependent upon individual needs of the patient. Potassium phosphate is used to treat or prevent hypophosphatemia (low blood levels of phosphorus). Potassium phosphate may also be used for purposes not listed in this medication guide. • Use SODIUM phosphate for patients with serum potassium > 4.5 mEq/L and serum sodium < 145mEq/L Talk to your doctor if you have concerns about this. Your list will be saved and can be edited at any time. IV Drug Compatibility Chart A ... (Protonix) Phenytoin (Dilantin) Potassium chloride Propofol (Diprivan) Sodium bicarbonate Sodium nitroprusside (Nipride) Succinylcholine (Anectine) Verapamil ... Clindamycin Phosphate Clorfarabine Cyclosporine Cytomegalovirus Immune Globulin Intravenous, Human Dacarbazine Daclizumab Calculate how many millimoles of elemental phosphorus are indicated. Potassium dihydrogen phosphate (each 10mL ampoule contains 10mmol potassium ions, 10mmol phosphate ions and 20mmol hydrogen ions) 250-500mL bag of sodium chloride 0.9% or glucose 5% 5. CLINICAL PRACTICE Administration of intravenous phosphate must be by a Registered Nurse or Midwife. With orders for IV phosphate, there is considerable confusion associated with the use of millimoles (mmol) versus milliequivalents (mEq) to express the phosphate requirement. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. Either a higher dose or the subsequent administration of more potassium phosphate may be required to normalize serum phosphate concentrations. This is a decision you and your doctor will make. Most Contains mixture of monobasic potassium phosphate and dibasic potassium phosphate, The dose and administration IV infusion rate for potassium phosphates are dependent upon individual needs of the patient, Phosphorous serum level <0.5 mg/dL: 0.5 mmol/kg IV infused over 4-6 hr, Phosphorous serum level 0.5-1 mg/dL: 0.25 mmol/kg IV infused over 4-6 hr, Prevention of hypophosphatemia (eg, in TPN): 20-40 mmol/day IV admixed in TPN is typical dose, but adjustment according to electrolyte levels is ongoing, Calculate concomitant amount of potassium that will be administered: Each 1 mmol of phosphate contains ~1.5 mEq of potassium; if amount of potassium to be delivered is a concern (ie, potassium serum level >4.0 mEq/L), consider use of sodium phosphates IV to replete phosphorous level, May require continuous EKG monitoring depending on potassium administration rate, Administration of solutions containing potassium and phosphorous in patients with impaired renal function may result in hyperkalemia or hyperphosphatemia, Caution should be exercised in premature neonates due to aluminum toxicity, Hypercalcemia or significant hypocalcemia, Severe renal impairment (eGFR <30 mL/min/1.73m2 and end stage renal disease, Inappropriate intravenous administration of undiluted or insufficiently diluted potassium phosphates as a rapid “IV push” has resulted in cardiac arrest, cardiac arrhythmias, hypotension, and death, Drug is for intravenous infusion only after dilution or admixing; maximum initial or single dose of potassium phosphate injection in intravenous fluids to correct hypophosphatemia is phosphorus 45 mmol (potassium 71 mEq); recommended infusion rate is approximately phosphorus 6.4 mmol/hr (potassium 10 mEq/hour); continuous electrocardiographic (ECG) monitoring is recommended for higher infusion rates, Intravenous infusion of phosphate has been reported to cause a decrease in serum magnesium (and calcium) concentrations when administered to patients with hypercalcemia and diabetic ketoacidosis; monitor serum magnesium concentrations during treatment, Intravenous administration of potassium phosphates to correct hypophosphatemia in single doses of phosphorus 50 mmol and greater and/or at rapid infusion rates (over 1 to 3 hours) in intravenous fluids has resulted in death, cardiac arrest, cardiac arrhythmia (including QT prolongation), hyperkalemia, hyperphosphatemia, and seizures, Phosphorus replacement therapy with potassium phosphates should be guided primarily by the serum inorganic phosphorus levels and the limits imposed by the accompanying potassium (K+) ion, To avoid hyperkalemia or hyperphosphatemia, infuse IV solutions containing potassium phosphates slowly, Caution with severe renal or adrenal insufficiency due to risk for hyperkalemia or hyperphosphatemia, High concentrations of phosphorus may cause hypocalcemia and hypocalcemic tetany; monitor calcium levels, Administration of pproved recommended dose of potassium phosphate injection is not expected to cause major birth defects, miscarriage, or adverse maternal or fetal outcomes; animal reproduction studies have not been conducted with intravenous potassium phosphates, Phosphorus is an essential mineral element; parenteral supplementation with potassium phosphates should be considered if pregnant woman’s requirements cannot be fulfilled by oral or enteral intake, Phosphorus and potassium are present in human milk; administration of approved recommended dose is not expected to cause harm to breastfed infant; there is no information on effects of potassium phosphates on milk production; developmental and health benefits of breastfeeding should be considered along with mother’s clinical need for drug and any potential adverse effects on breastfed infant from therapy or from underlying maternal condition. Call your doctor right away if you have chest pain or trouble breathing. Potassium phosphate side effects (in more detail). For potassium phosphate, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to potassium phosphate or any other medicines. Criteria for IV to PO conversion is met (including patients who are NPO except meds) 2. Limitations of Use Safety h… It is also used as an additive in the preparation of fluid formula injections. Most Potassium phosphate may also increase your risk of having blood clots in the lungs. If the serum potassium is 4.0 mg/dL, administer as potassium phosphate. This drug is available at a higher level co-pay. Drugs, 2010 Potassium phosphate may increase your risk of having serious heart or heart rhythm problems (eg, QT prolongation). That is used to treat or prevent hypophosphatemia ( low magnesium in the same class care may! 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